2014 Fiscal Year Final Research Report
Application of genome informatics for the molecular targeting therapy against cholangiocarcinoma
| Project/Area Number |
24591006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TATEISHI Keisuke 東京大学, 医学部附属病院, 講師 (20396948)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 胆道癌 / ヒストン修飾 |
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| Outline of Final Research Achievements |
Recent reports have documented gene mutations found in cholangiocellular carcinoma by comprehensive genomic analysis, however it remains unknown whether or how the mutations contribute to malignant features of cholangiocarcinoma. The status of epigenome as well as genome is suspected as the significant factor for tumor characteristics. In this research, we address the role of alteration of genome and epigenome in cholangiocarcinoma.
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| Free Research Field |
消化器内科学
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