The impact of macrophage transcription factor MafB on rupture of abdominal aortic aneurysm

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591033
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Yamagata University
• Principal Investigator: WATANABE Tetsu 山形大学, 医学部, 講師 (40359568)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 腹部大動脈瘤 / マクロファージ / MafB

Outline of Final Research Achievements

Transcription factor MafB is expressed only in monocytes and macrophages among hematopoietic cells, which plays a role in the terminal differentiation of macrophages. MafB knockout mice die immediately after birth due to developmental anomalies of neurons in the respiratory centre. We generated transgenic mice that express dominant negative (DN) MafB capable of suppressing endogenous MafB transcription activity only in macrophages. The abdominal aortic aneurysm (AAA) model was developed by 1000 ng/kg/min of angiotensin II infusion in apolipoprotein E-deficient (ApoE KO) mice and ApoE KO/DN MafB mice. There was no difference in development of AAA between ApoE KO mice and ApoE KO/DN MafB mice. We investigate impact of MafB on rupture of AAA.

Free Research Field

循環器内科学