Analysis of pathophysiologic and genetic mechanisms and establishment of treatment therapy in J wave syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591052
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Okayama University
• Principal Investigator: NAGASE Satoshi 岡山大学, 医歯(薬)学総合研究科, 助教 (50397907)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Kazufumi 岡山大学, 医歯薬学総合研究科, 准教授 (10335630) ; MORITA Hiroshi 岡山大学, 医歯薬学総合研究科, 教授 (50322227) ; NISHII Nobuhiro 岡山大学, 医歯薬学総合研究科, 講師 (50537214) ; KUSANO Kengo 独立行政法人国立循環器病研究センター, 心臓血管内科, 部長 (60314689)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: J波症候群 / Brugada症候群 / 遺伝子解析 / 心臓電気生理検査 / 心臓突然死

Outline of Final Research Achievements

We performed epicardial electrogram recording in left ventricle (LV) in 60 patients with J wave syndrome and 10 control subjects. Epicardial recording in LV revealed that prominent J wave or ST-segment elevation was more prevalent in symptomatic patients than that in asymptomatic patients. Prominent J wave in LV epicardium was coincided with the J wave in surface electrocardiogram. Prominent epicardial J wave was attenuated with constant atrial pacing and exaggerated with administration of pilsicainide. Epicardial electrogram recording in LV might be useful for prediction of fatal arrhythmic event in patients with J wave syndrome.

Free Research Field

循環器内科学