The evaluation of CD44 in pathogenesis of abdominal aortic aneurysm and the development of new therapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591053
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Okayama University
• Principal Investigator: MIYOSHI Toru 岡山大学, 大学病院, 講師 (70444651)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Kazufumi 岡山大学, 医歯薬学総合研究科, 准教授 (10335630) ; YONEZAWA Tomoko 岡山大学, 医歯薬学総合研究科, 助教 (30304299) ; YOSHIDA Masashi 岡山大学, 医歯薬学総合研究科, 助教 (70532761)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 腹部大動脈瘤 / CD44 / 炎症性遺伝子 / 動脈硬化 / サイトカイン

Outline of Final Research Achievements

Immunohistochemical analysis of human abdominal aortic aneurysm revealed that the increased expression of CD44 and the degradation of hyaluronic acid were possibly involved in pathogenesis of abdominal aortic aneurysm. Experimental abdominal aortic aneurysm using CaCl2-induced model, the incidence of abdominal aortic aneurysm was significantly less in CD44 knockout mice compared to wild type mice. Liposome targeting CD44 was developed and the utility of its liposome is being studied.

Free Research Field

循環器内科学