2014 Fiscal Year Final Research Report
The role of LR11,proliferation marker of Vascular smooth muscle cell for Pulmonary hypertension
| Project/Area Number |
24591069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 肺高血圧症 / 血管平滑筋細胞 / LR11 / バイオマーカー |
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| Outline of Final Research Achievements |
Pulmonary arterial hypertension (PAH) is pathophysiologically characterized with medial thickening of smooth muscle cells (SMCs). LR11 is expressed in intimal smooth muscle cells. This study examined the role of LR11 in pulmonary hypertension.The expression LR11, together with HIF-1α was significantly increased under hypoxic conditions compared with normoxia in mouse lung. Serum sLR11 levels were increased under hypoxic condition. The increased right ventricular systolic pressure, right ventricular hypertrophy and medial thickening in wild-type mice were attenuated in KO mice. The expression of LR11 and HIF-1α was increased in cultured SMCs under hypoxic conditions and the knockdown of HIF-1α abolished the hypoxia-induced LR11 induction. Human study showed that serum sLR11 levels were significantly higher in patients with PAH.The sLR11 levels were positively correlated with pulmonary vascular resistance and mean pulmonary arterial pressure.Soluble LR11 may be a novel biomarker.
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| Free Research Field |
循環器内科
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