2014 Fiscal Year Final Research Report
Impacts of Protein Quality Control in Cardiac Remodeling after Myocardial Infarction
| Project/Area Number |
24591092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 慢性心不全 / 心臓リモデリング / 心筋梗塞 / 心破裂 / ユビキチンプロテオソーム |
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| Outline of Final Research Achievements |
Left ventricular (LV) remodeling following myocardial infarction (MI) has an important role on global cardiac function. Muscle atrophy F-box (MAFbx), an E3 ubiquitin ligase, induces skeletal muscle atrophy and cardiac remodeling under the condition of pressure overload, but the roles of MAFbx in MI is not well understood. Our aim is to determine if MAFbx contribute to cardiac remodeling following MI. MAFbx-knockout (KO) and wild-type (WT) mice were subjected to permanent coronary ligation to create MI. The infarct sizes 3 days after MI were not significantly different in WT and MAFbx KO mice. In comparison with WT mice, MAFbx KO mice were protected against early mortality due to cardiac rupture. MMP9 activity in risk areas 3 days after MI was significantly reduced in KO mice than in WT mice.
MAFbx protein level increase in acute phase after MI. Gene deletion of MAFbx deletion reduces mortality after MI and cardiac rupture, decreasing the activity of MMP9.
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| Free Research Field |
循環器内科学
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