Development of new intervention by nutritional rehabilitation in COPD

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591124
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Akita University
• Principal Investigator: SHIOYA Takanobu 秋田大学, 医学(系)研究科(研究院), 教授 (90170852)
• Co-Investigator(Kenkyū-buntansha): SATAKE Masahiro 秋田大学, 大学院医学系研究科, 准教授 (10250903) ; WATANABE Hiroyuki 秋田大学, 大学院医学系研究科, 准教授 (80323145) ; SANO Masaaki 秋田大学, 大学院医学系研究科, 講師 (30323140)
• Research Collaborator: TAKAHASHI Hitomi 市立秋田総合病院, リハビリ科, 技師長 ; SUGAWARA Keiyu 市立秋田総合病院, リハビリ科, 副技師長 ; KAWAGOSHI Atsuyoshi 市立秋田総合病院, リハビリ科, 技師
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 栄養リハビリテーション / 呼吸リハビリテーション / 運動療法 / 栄養療法 / 慢性閉塞性肺疾患(COPD) / サルコペニア

Outline of Final Research Achievements

The aim of this study was to investigate the effectiveness of nutritional supplementation therapy with low-intensity exercise therapy in patients with COPD. In stable elderly COPD patients, anti-inflammatory nutritional supplementation therapy was added to low-intensity exercise therapy. COPD patients were divided into those with and those without the ingestion of nutritional supplement containing whey peptide, which exhibited an anti-inflammatory effect. The body composition, skeletal muscle strength, exercise tolerance, health-related QOL (HRQOL), and inflammatory cytokines were evaluated before and three months after intervention. In the nutritional support group, the body weight, lower muscle force, respiratory muscle force and CRQ score were significantly increased, and the levels of inflammatory cytokines were reduced significantly. These data suggested usefulness of nutritional rehabilitation which was consisted of nutritional therapy and exercise therapy.

Free Research Field

呼吸リハビリテーション　呼吸器内科