Analysis of particulate-induced allergic responses

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591145
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Osaka University
• Principal Investigator: Kuroda Etsushi 大阪大学, 免疫学フロンティア研究センター, 特任准教授 (10299604)
• Co-Investigator(Kenkyū-buntansha): 森本 泰夫 産業医科大学, 産業生態科学研究所, 教授 (30258628)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 粒子状物質 / アラム / シリカ / IgE / ダメージ関連分子パターン

Outline of Final Research Achievements

Recently, the number of patients suffering from allergic diseases has increased especially in developed countries, and many studies have demonstrated that particle pollutants and environmental particles such as diesel exhaust, sand dust and PM2.5 may exacerbate allergic responses mediated by type 2 immune responses. However, the mechanisms by which particulates elicit type 2 responses remain poorly understood.
Intratracheal instillation of particulates and OVA induced antigen-specific IgE responses. These responses were regulated by a MyD88 dependent and IL-1 signaling pathway. Particulates stimulated alveolar macrophages to induce cell death and IL-1α release both in vitro and in vivo. Our results suggest that DAMPs released by particulate exposure play an important role in IgE induction and inflammation.

Free Research Field

免疫学