2014 Fiscal Year Final Research Report
Search of the effect predictive factor in molecules target therapy for lung cancer
| Project/Area Number |
24591156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Satoshi 新潟大学, 医歯学総合病院, 特任助教 (50529740)
NAKATA Koh 新潟大学, 医歯学総合病院, 教授 (80207802)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | Lung cancer / EGFR-TKI / MDSCs / Predictive factor |
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| Outline of Final Research Achievements |
Several immunologic parameters in patients with positive EGFR-mutation NSCLC during initial EGFR-TKI treatment were measured. The tendency that decreased frequency in the peripheral blood of the CD4+ CD25+ Foxp3+Regulatory T cell during tumor regression was found. In contrast, analysis of MDSCs or various humoral factors showed no particular tendency. During the series of experiments, we found that DDX3X expression and CD4+ CD25+ Foxp3+ Regulatory T cell affecting acquisition of resistancy to TKI.
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| Free Research Field |
医歯薬学
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