Analysis of Glomerular Injury: The Signal Transduction Pathway of Bowman's Epithelial Cells"

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591188
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Gunma University
• Principal Investigator: HIROMURA Keiju 群馬大学, 医学(系)研究科(研究院), 准教授 (70292597)
• Co-Investigator(Renkei-kenkyūsha): SAKAIRI Toru 群馬大学, 大学院医学系研究科, 助教 (20455976)
• Research Collaborator: STUART Shankland University of Washington, Division of Nephrology, Professor
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ボウマン嚢上皮細胞 / 糸球体障害 / sestrin 2 / mTOR経路 / ネフローゼ症候群 / 蛋白尿

Outline of Final Research Achievements

In the current study, we have shown that sestrin 2, a novel stress-inducible protein, is selectively expressed Bowman's epithelial cells of normal rat kidney. In rat model of nephrotic syndrome (minimal change or focal segmental glomerulosclerosis) and crescentic glomerulonephritis, sestrin 2 expression was decreased, demonstrating that decreased expression of Sestrin 2 could be a novel marker of Bowman’s epithelial cell injury. In addition, mTOR pathway, which is the downstream of target of sestrin 2, was up- or down-regulated by the changes of sestrin 2 expression, suggesting that sestrin 2-mTOR pathway could be a target of treatment for glomerular injury.

Free Research Field

腎臓病学