Research for investigation of pathogenesis of nephropathy in low-birth-weight individuals

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591222
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Kidney internal medicine
• Research Institution: Clinical research Center, Chiba-East National Hospital, National Hospital Organization
• Principal Investigator: Imasawa Toshiyuki 独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, その他 (80348276)
• Research Collaborator: TANAKA Masashi 東京都健康長寿医療センター, 健康長寿ゲノム探索研究チーム, リーダー ; YAMAGUCHI Yutaka 前東京慈恵会医科大学, 柏病院病理学, 教授 ; Rossignol Rodrigue INSERM(U688 Physiopathologie Mitochondriale), Bordeaux Univ
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: ミトコンドリア / 巣状分節状糸球体硬化症 / 低出生体重 / 糖尿病性腎症 / エネルギー代謝 / 糸球体上皮細胞

Outline of Final Research Achievements

The main results are;
1.Establishment of rat model of low-birth-weight related nephropathy, which resembles human low-birth-weight related nephropathy; 2.Elucidation of decreased mitochondrial function, for examples decreased OXPHOS complex subunits and decreased enzymes of TCA cycle, in kidneys in low-birth-weight rats mainly by proteome analysis; 3.Elucidation of well-developed mitochondrial networks in human podocytes (HPs) in vivo and in vitro; 4.Elucidation of processes and mechanism how HP develop their energy metabolic systems; 5.Elucidation of HPs change their energy metabolic system to glycolysis-dependent way in high glucose by using human podocyte cell line

Free Research Field

腎臓内科