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2014 Fiscal Year Final Research Report

Clinical application of q space imaging

Research Project

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Project/Area Number 24591302
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

MAKINO Masahiro  京都府立医科大学, 医学(系)研究科(研究院), その他 (80271162)

Co-Investigator(Kenkyū-buntansha) MIZUNO Toshiki  京都府立医科大学, 大学院医学研究科, 教授 (30264782)
YAMADA Kei  京都府立医科大学, 大学院医学研究科, 教授 (80315960)
KONDO Masaki  京都府立医科大学, 大学院医学研究科, 助教 (20315964)
Project Period (FY) 2012-04-01 – 2015-03-31
KeywordsMRI / q space imaging / CADASIL / 脳血管性認知症
Outline of Final Research Achievements

Q-Space imaging is a novel magnetic resonance technique that enables the assessment of ultrastructural changes of white matter. We hypothesized that this technique would facilitate the assessment of vascular dementia, such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).
Six CADASIL patients were studied. Q-Space imaging was performed using a single shot, echo-planar imaging technique. Both q-space imaging and ADC maps depicted progressive neuronal damage. Early neuronal damage was especially well depicted using q-space imaging, with preferential involvement of the frontal lobes and central gray matters. Visual assessment of images revealed a trend for occipital lobe sparing, especially on q-space imaging. Q-Space imaging demonstrated early neuronal damage in CADASIL. Since this method appears to be sensitive to early neuronal damage, it could conceivably aid in evaluating vascular dementia.

Free Research Field

脳血管障害

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Published: 2016-06-03  

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