The role of innate immunity in the pathogenesis of fulminant type 1 diabetes.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591321
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: University of Yamanashi
• Principal Investigator: AIDA Kaoru 山梨大学, 総合研究部, 准教授 (50184015)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Tetsuro 公益財団法人冲中記念成人病研究所, 研究室, 研究員 (30113442)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 劇症１型糖尿病 / 自然免疫 / ウイルス感染 / エンテロウイルス

Outline of Final Research Achievements

We showed the presence of enterovirus proteins in the patients pancreas from the fulminant type 1 diabetes (FT1D). In this project, Proteins expressed in the islets of enterovirus-associated fulminant type 1 diabetes (FT1DM) with extensive insulitis were identified by laser-capture microdissection mass spectrometry using formalin-fixed paraffin-embedded pancreatic tissues. The cellular localization of selected proteins was validated immunohistochemically. Thirty-eight proteins were identified solely in FT1DM islets, most of which have not been previously linked to type 1 diabetes. Those are proteins involved in successive signaling in innate/adaptive immunity, migratory activity-related proteins and proteins related to virus replication and cell proliferation. The identified FT1DM-characterizing proteins include those involved in aggressive beta cell destruction

Free Research Field

代謝・内分泌