2014 Fiscal Year Final Research Report
Elucidation of the mechanism of pancreatic beta-cell differentiation and regeneration using inducible cell labeling system
| Project/Area Number |
24591330
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kobe University |
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Principal Investigator |
MIANMI KOHTARO 神戸大学, 医学(系)研究科(研究院), 准教授 (80334176)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 糖尿病 / 糖代謝異常 |
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| Outline of Final Research Achievements |
In the present study, we chased the fate of pancreatic beta cells by utilizing inducible cell labeling system. In alloxan-induced diabetic mice, the human GLP-1 receptor agonist liraglutide restored function and mass of beta cells. Liraglutide increased beta cell proliferation and decreased beta cell death, but did not induce neogenesis of beta cells.
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| Free Research Field |
医歯薬学
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