2014 Fiscal Year Final Research Report
A study of neuronal and hormonal mediations of insulin secretion by inretins.
| Project/Area Number |
24591340
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | insulin secretion / incretin / diabetes / membrane potential |
|---|
| Outline of Final Research Achievements |
In this stduy, we clarified the mechanistic pathway for stimulation of insulin secretion by incretins that include GLP-1 and GIP. These hormones open TRPM2 channel (transient receptor potential channe) that is a class of background current channel and its openings evoke increase in membrane excitability of pancreatic beta cells and consequently potentiate insulin secretion induced by glucose. We are expecting a novel antidiabetic drugs development as a target site against this channel protein.
|
| Free Research Field |
endocrinology and metabolism
|
