2014 Fiscal Year Final Research Report
Analysis of glucagon seceretion mechanisms and its modulation by anti-diabetes drugs
| Project/Area Number |
24591343
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Suguru 日本大学, 医学部, 助教 (70451614)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Mayumi 日本大学, 医学部, 講師 (80349993)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | グルカゴン / インクレチン / スルホニル尿素受容体 / DPP-4阻害薬 / メトホルミン |
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| Outline of Final Research Achievements |
Increased glucagon secretion is an essential pathogenic abnormality found in type 2 diabetes patients. In this study, we have conducted several experiments aiming to elucidate mechanisms of glucagon secretion and to apply the results for analyzing pathogenesis of type 2 diabetes in humans. We found that modulation of the sulfonylurea receptor signaling by zinc and GLP-1 could be involved in glucagon secretion, providing insights for further analysis on its mechanisms. We have also conducted a clinical study in which type 2 diabetes patients on insulin monotherapy were treated either with sitagliptin, a DPP-4 inhibitor, or metformin, a biguanide compound. We have demonstrated that sitagliptin improved glycemic control by reducing glucagon secretion. In parallel, we have compared glucagon immunoassays, and found that a newly developed glucagon ELISA revealed more dynamic changes in glucagon after a meal challenge test.
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| Free Research Field |
代謝学
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