2014 Fiscal Year Final Research Report
Analysis of molecular mechanism in leukemogenesis through an epigenome regulator
| Project/Area Number |
24591390
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Mie University |
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Principal Investigator |
ONO RYOICHI 三重大学, 医学(系)研究科(研究院), 講師 (40422414)
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| Co-Investigator(Renkei-kenkyūsha) |
NOSAKA Tetsuya 三重大学, 大学院医学系研究科, 教授 (30218309)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 白血病 |
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| Outline of Final Research Achievements |
In this study, to focus on epigenetic alterations closely associated with leukemogenesis, I have generated conditional knockout mice of an epigenome regulator, analyzed malignant hematopoiesis of these mice combined with my leukemogenic mouse model, and characterized normal hematopoiesis of the mice. Conditional ablation of the target molecule induced no critical phenotypic changes in leukemogenesis, but led to interesting findings concerning self-renewal and differentiation of hematopoietic stem cells. I am further investigating the molecular mechanisms at the moment.
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| Free Research Field |
血液内科学
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