2015 Fiscal Year Final Research Report
Analysis of the genetic background of Sjogren's syndrome
| Project/Area Number |
24591436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | シェーグレン症候群 / 疾患感受性遺伝子 / 遺伝子多型 |
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| Outline of Final Research Achievements |
Genomic DNA samples from 190 primary Sjogren's syndrome (SS) patients and ethnically matched 428 healthy controls were collected. Several lupus susceptible genes were evaluated using TaqMan Genotyping Assay. The allele frequencies of lupus risk in SS were significantly higher in BLK (odds ratio (OR) =1.61, 95% confidence interval (CI):1.21-2.15), STAT4 (OR=1.83, 95%CI:1.43-2.36), IRF5 (OR=1.40, 95%CI:1.07-1.82) and rs10798269 in 1q25.1 region (OR=1.62, 95%CI:1.20-2.18), compared with those in healthy controls. No significant associations were found in BANK1, TNFSF13, TNFAIP3 and TNFSF4. BLK, STAT4, IRF5 and 1q25.1 region were not only lupus susceptible genes but SS susceptible genes in Japanese population. SS share, in part, common genetic background with SLE.
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| Free Research Field |
リウマチ・膠原病、臨床免疫学
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