The examination of utility of MRI bone edema in early rheumatoid arthritis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591451
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Nagasaki University
• Principal Investigator: TAMAI Mami 長崎大学, 医歯薬学総合研究科(医学系), 講師 (60380862)
• Co-Investigator(Kenkyū-buntansha): ARIMA Kazuhiko 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30423635) ; UETANI Masataka 長崎大学, 医歯薬学総合研究科(医学系) (40176582) ; OHYAMA Kaname 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (50437860) ; AOYAGI Kiyoshi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80295071) ; KAWAKAMI Atsushi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90325639)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 関節リウマチ / MRI骨髄浮腫 / 診断 / X線進行予測

Outline of Final Research Achievements

The aim of this study is to examine the utility of MRI findings, especially bone edema, in patients with early-stage RA from Nagasaki University Early Arthritis Cohort. First, we found that MRI bone edema could improve the diagnostic performance of 2010 RA classification criteria (sensitivity 62 to 76% and accuracy 70 to 76%) in 166 early RA whose duration within 6 months (median 2 months). Second, we found that MRI bone edema at baseline could predict the development of rapid radiographic progression (RRP) (Odds ratio 2.18) in 76 early RA patients (median duration 3 months, RRP 15%, RF 79%, ACPA 82%). In addition, MRI bone erosion involved in poor radiographic outcome in early-stage RA patients even successfully treated by T2T strategy (Odds ratio 3.00) in the same 76 patients.

Free Research Field

膠原病・アレルギー内科学