Analysis of the mechanism of sublingual immunotherapy in murine asthma model

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591462
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Niigata University
• Principal Investigator: KOYA TOSHIYUKI 新潟大学, 医歯学総合病院, 講師 (90444158)
• Co-Investigator(Kenkyū-buntansha): HASEGAWA Takashi 新潟大学, 医歯学総合病院, 准教授 (90361906) ; SAKAGAMI Takuro 新潟大学, 医歯学系, 助教 (00444159)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 気管支喘息 / 舌下免疫療法 / Dermatophagoides farina / IgA

Outline of Final Research Achievements

Allergen specific sublingual immunotherapy is less of anaphylaxic reactions and is possible to maintain the therapy at home. However, the mechanisms of immunotherapy, including sublingual immunotherapy, are not elucidated entirely. In this study, we used Dermatophagoides farina-specific asthma model and executed sublingual immunotherapy to them. In sublingual immunothepy groups, airway hyperresponsiveness to methacholine, airway eosinophilic inflammation and airway remodeling were suppressed compared to control group. Serum IgE levels were decreased and IgG levels were increased after immunotherapy. Moreover, IgA levels of BAL fluid were also increased compared to control group. These data suggested that increasing IgG or IgA presumably play as a blocking antibody to mast cell and the alteration of dendritic cell function through Fc receptor might be the mechanism of immunotherapy.

Free Research Field

呼吸器・アレルギー