IL-33 expression in lymphoid tissues

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591475
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Tokyo Metropolitan Institute of Medical Science (2013-2014); National Research Institute for Child Health and Development (2012)
• Principal Investigator: OBOKI Keisuke 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主席研究員 (80415108)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: IL-33

Outline of Final Research Achievements

Clarification of IL-33-expressing cells and the regulatory mechanisms of IL-33 expression have a potential for identification of a new drug for asthma. Recently, another research reported IL-33 reporter mice on Journal of Immunology, 2012. Thus, we have attempted to study by another approach. Besides, a collaborative study which reported IL-33 function in memory Th2 cells has been published (Immunity 2015). Furthermore, given that Gauvreau et al.(2014) reported that anti-TSLP Ab treatment would be a promising drug for asthma (TSLP is one of the asthma-related genes reported form GWAS studies), it is also expected that inhibition of IL-33 or of IL-33-IL-33R pathway will show the possibility of success as a novel promising drug-target for asthma (IL-33 and IL-33R are also asthma-related genes reported from GWAS studies).

Free Research Field

分子生物学