Infectious mechanism of H5N1 virus to human respiratory epithelial cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591480
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: DAIDOJI TOMO 京都府立医科大学, 医学(系)研究科(研究院), 助教 (80432433)
• Co-Investigator(Kenkyū-buntansha): WATANABE Yohei 京都府立医科大学, 医学研究科・感染病態学, 講師 (50452462)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 高病原性鳥インフルエンザウイルス

Outline of Final Research Achievements

The purpose of this study was to reveal the mechanisms responsible for the difference in infectivity between the current H5N1 and previously circulating avian influenza viruses. Current H5N1 has a broader tropism for human respiratory epithelial cell clones with different membrane fusion activity compared with previously circulating strains. The endosomal environment of high-susceptibility cell clones is different from that of low-susceptibility cell clones. Avian influenza virus infection of human respiratory epithelial cells depends on both viral membrane fusion activity and host endosomal environment.

Free Research Field

ウイルス学