The elucidation of prion infectious mechanism on host innate immunity

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591482
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Nagasaki University
• Principal Investigator: ISHIBASHI Daisuke 長崎大学, 医歯薬学総合研究科(医学系), 助教 (10432973)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: prion / innate immunity / IRF3 / IFN / Oct-1

Outline of Final Research Achievements

In this study, we focused the innate immune system in host, and examined the relationship between prion infection and the immune system. As a result, we revealed that IRF3-type I IFNs system plays a key role in prion infection and that the expression of Oct-1, which is a selectively transcription factor of IRF3 gene, is negatively controlled by prion infection. Consequently, we consider that development of prevention and therapeutic agent against the prion disease, which targets this innate immune system, would progress by our project.

Free Research Field

ウイルス学、免疫学、分子生物学