Endothelial cell dysfunction in the pathogenesis of influenzavirus myocarditis, and treatment of influenzavirus myocarditis.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591493
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Osaka Medical College
• Principal Investigator: UKIMURA Akira 大阪医科大学, 医学部, 教授 (50257862)
• Co-Investigator(Kenkyū-buntansha): KANZAKI Yumiko 大阪医科大学, 医学部, 講師 (80445999)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: インフルエンザ / 心筋炎 / ノイラミニダーゼ阻害薬 / 血管内皮機能障害

Outline of Final Research Achievements

Proinflammatory cytokines and endothelial cell dysfunction are thought to contribute to the pathogenesis of influenza myocarditis.
To analyze the effects of peramivir on influenza A virus myocarditis, we investigated cardiac function, histological findings and cytokine induction in murine influenza A virus-induced myocarditis. Fractional shortening of peramivir-treatment group was significantly higher than that of control group. Histological examinations revealed localized myocarditis with lymphocyte infiltration, and myocarditis lesions were found in perivascular areas or associated with pericarditis. Treatment with peramivir improved these findings. The expression of cytokine and adhesion molecule mRNA was suppressed in peramivir-treatment group. Peramivir may have potentiality to suppress pro-inflammatory cytokines and improve endothelial dysfunction.

Free Research Field

感染症内科学