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2014 Fiscal Year Final Research Report

Selective Development of Myogenic Mesenchymal Cells from Human Embryonic and Induced Pluripotent Stem Cells

Research Project

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Project/Area Number 24591508
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionKyoto University

Principal Investigator

KATO Takeo  京都大学, 医学(系)研究科(研究院), 助教 (60422945)

Co-Investigator(Kenkyū-buntansha) AWAYA Tomonari   (20589593)
Project Period (FY) 2012-04-01 – 2015-03-31
KeywordsiPS細胞 / 骨格筋分化誘導
Outline of Final Research Achievements

we developed a novel stepwise culture method for the selective expansion of mesenchymal cells from
cell aggregations called embryoid bodies. These mesenchymal cells, which were obtained by dissociation and re-cultivationof embryoid bodies, uniformly expressed CD56 and the mesenchymal markers CD73, CD105, CD166, and CD29, and finally differentiated into mature myotubes in vitro. Furthermore, these myogenic mesenchymal cells exhibited stable long-term engraftment in injured muscles of immunodeficient mice in vivo

Free Research Field

小児神経

URL: 

Published: 2016-06-03  

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