2014 Fiscal Year Final Research Report
Identification of immune cells involved in chronic graft-versus-host disease and its disease control
| Project/Area Number |
24591543
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Research Collaborator |
ARAKI Raita
KURODA Rie
MASE Shintaro
MAEBA Hideaki
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 造血幹細胞移植 / 移植片対宿主病 / 肥満細胞 |
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| Outline of Final Research Achievements |
Originally mast cells have been known as effector cells in the IgE-mediated allergic responses. In addition, recent studies demonstrated that mast cells exerted pro-inflammatory or anti-inflammatory effects in complicated immune response depending on the situation. In allogeneic hematopoietic stem cell transplantation (HSCT), exact role of mast cells in graft-versus-host disease (GVHD) remains unclear.
Firstly, we have demonstrated that both host-type and donor-type mast cells suppressed mixed lymphocyte reaction in vitro. Secondly, we have shown that absence of both host-typed and donor-typed mast cells exacerbated acute GVHD utilizing mast cell deficient mice. Taken together, mast cells have a protective role against GVHD and cell therapy using cultured mast cell would be promising for refractory GVHD in clinical settings.
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| Free Research Field |
造血幹細胞移植
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