2014 Fiscal Year Final Research Report
Exploration for therapeutic target using a novel prognostic factor IKZF1 targeting cells in childhood acute lymphoblastic leukemia
| Project/Area Number |
24591568
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | National Hospital Organization Nagoya Medical Center |
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Principal Investigator |
HATTORI Hiroyoshi 独立行政法人国立病院機構(名古屋医療センター臨床研究センター), その他部局等, その他 (20624513)
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| Co-Investigator(Kenkyū-buntansha) |
HORIBE Keizo 独立行政法人国立病院機構名古屋医療センター, 臨床研究センター, 臨床研究センター長 (30209308)
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| Research Collaborator |
SAITO Yuko
YAMASHITA Yuka
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 小児急性リンパ性白血病 / 抗がん剤感受性 / 予後因子 |
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| Outline of Final Research Achievements |
Patients with childhood acute lymphoblastic leukemia (ALL) in high risk recur about 30%. Recently, IKZF1 alteration in genomic DNA has been found as a prognostic factor. To elucidate the role of the IKZF1 alteration, we developed childhood ALL model cells with IKZF1 mutations. We investigated the relationship between the IKZF1 alteration and anti-cancer drug sensitivity which are frequently used in childhood ALL. The results showed the sensitivity to the several drugs may be dependent on the IKZF1 alteration.
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| Free Research Field |
小児血液腫瘍学
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