2014 Fiscal Year Final Research Report
Phosphodiesterase inhibitors inhibit Lactobacillus casei cell-wall-induced inflammations
| Project/Area Number |
24591572
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Kunio 金沢大学, 医学系, 准教授 (00303280)
SUGIMOTO Naotoshi 金沢大学, 医学系, 准教授 (80272954)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 小児科 / 循環器 |
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| Outline of Final Research Achievements |
Kawasaki disease patients show the symptoms of a fever and vasculitis, and sometimes severe coronary artery aneurysm. This coronary artery aneurysm might result in lowering the QOL of children. Lactobacillus Lactobacillus casei cell wall fragments (LCWE) make similar Kawasaki disease in animals. Previously we showed that cAMP down-regulates the inflammatory response. In this study, we revealed that cAMP inhibits the LCWE-induced NF-kappaB and MAPK pathways, and cell proliferation. In addition, both the signals of pretein kinase A (PKA) and Epac that are downstream of cAMP are involved.
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| Free Research Field |
医歯薬学
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