The role of perivascular sympathetic nerve in the development of experimental pulmonary arterial hypertension and the effect of endothelin on vascular innervation

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591573
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nagoya University
• Principal Investigator: KATO TAICHI 名古屋大学, 医学部附属病院, 講師 (20422777)
• Co-Investigator(Kenkyū-buntansha): FUKASAWA Yoshie 名古屋大学, 医学部附属病院, 病院助教 (00612764)
• Co-Investigator(Renkei-kenkyūsha): SATO Yoshiaki 名古屋大学, 医学部附属病院, 講師 (30435862)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肺高血圧症 / 交感神経 / リモデリング

Outline of Final Research Achievements

In this study, the role of perivascular sympathetic nerve in the development of experimental pulmonary arterial hypertension and the effect of endothelin antagonist, ambrisentan, on vascular innervation were investigated. Perivascular sympathetic nerves around pulmonary arteries with the diameter of 50-200μm were very rare. On the other hand, more nerves were confirmed at larger pulmonary arteries. Perivascular sympathetic nerves at larger pulmonary arteries were decreased in pulmonary arterial hypertension group compared to control group. In addition, these distributions were not affected by ambrisentan. These results demonstrated the distribution of perivascular sympathetic nerve in the development of experimental pulmonary arterial hypertension. Furthermore, the effect of ambrisentan on vascular innervation was limited. Therefore, the other factors associated with decreased vascular sympathetic nerve remain to be elucidated.

Free Research Field

小児科学