The effect of cerebral white matter injury on the subsequent myelination in premature fetal sheep

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591597
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Tohoku University
• Principal Investigator: MATSUDA TADASHI 東北大学, 大学病院, 准教授 (50361100)
• Co-Investigator(Renkei-kenkyūsha): WATANABE Tatsuya 東北大学, 大学病院, 助教 (70400380) ; MATSUDA Tadashi 東北大学, 大学病院, 助教 (00451584) ; AKIYAMA Shizuko 東北大学, 大学病院, 助手 (80466549) ; ONODERA Sachiko 東北大学, 大学病院, 特任助手 (00509408)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳白質損傷 / 胎児 / 早産児 / 脳虚血 / 髄鞘化 / 核磁気共鳴画像法 / 免疫組織染色 / 電子顕微鏡

Outline of Final Research Achievements

We analyzed the association between histopathologic findings and magnetic resonance images using sheep fetuses experimentally induced cerebral white matter injury (WMI) by ischemic insults. First, all lesions of focal WMI were clearly observed as at once a high intensity spot of T1 weighted image and a low intensity spot of T2 weighted image in the magnetic resonance imaging. Second, diffuse WMI lesion was possibly shown as a high intensity region of T2 weighted image in the subacute phase (2-5 days) after the insults. In addition, an electron microscopic analysis might be quite useful to understand and detect the over-maturity of myelination induced by diffuse WMI.

Free Research Field

医歯薬学 内科系臨床医学 胎児・新生児医学 胎児医学