2015 Fiscal Year Final Research Report
Development of cerebrovascular protection therapy for neonatal hypoxic ischemic encephalopathy
| Project/Area Number |
24591601
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANIIKE MASAKO 大阪大学, 連合小児発達学研究科, 教授 (30263289)
WADA KAZUKO 大阪大学, 大学院医学系研究科, 講師 (30294094)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | プロスタグランディン / 低酸素性虚血性脳症 / iPS細胞 |
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| Outline of Final Research Achievements |
Hypoxic ischemic encephalopathy (HIE) in neonates is a leading cause of neurological impairment. We investigated the function of the prostaglandin in rodent models of neonatal HIE and human induced pluripotent stem cells (iPSCs). Pharmacologic activation of the EP4 receptor with a selective agonist (AE1-329) was significantly cerebroprotective through the improvement of cerebral perfusion. On the other hand, activation of EP2-4 receptors with the agonist misoprostol significantly reduced the oxidative stress in human iPSC-derived neural precursors subjected to oxygen glucose deprivation. These data indicate that the G-protein coupled EP receptors may be amenable to pharmacologic targeting in the acute setting of neonatal HIE.
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| Free Research Field |
胎児・新生児医学
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