Effects of periodic maternal separation on development of circadian rhythm in rat pups

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591602
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: The University of Tokushima
• Principal Investigator: SAKATA Hiromi 徳島大学, ヘルスバイオサイエンス研究部, 講師 (50294666)
• Co-Investigator(Kenkyū-buntansha): FUKUI Yoshihiro 徳島大学, 大学院ヘルスバイオサイエンス研究部, 教授 (50144168)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 概日リズム / 脳発達 / 深部体温 / 明暗周期 / 母仔分離 / ラット

Outline of Final Research Achievements

Rat pups under went the maternal separation during for
12 hours a day from postnatal days 13 with a synchronized timing of separation/cohabitation with light ON or OFF, or with 3-hour delayed timing from light ON or OFF. As a result, the emergence of a transient and acute decrease in deep body temperature, which is characteristic in prewearning pups, was entrained a light and dark cycle, but not timing of maternal separation/cohabitation. A maternal separation under constant lightness revealed that if there was no in light condition as a time cue, the transient and acute decrease in the deep body temperature entrained maternal separation/cohabitation.

Free Research Field

先天異常学