2014 Fiscal Year Final Research Report
Factors inhibit serine protease activity and echance epidermal differentiation in Papillon-Lefevre syndrome
Project/Area Number |
24591621
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Dermatology
|
Research Institution | Hirosaki University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
NAKANO Hajime 弘前大学, 大学院医学研究科, 准教授 (90281922)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | cathepsin C / inflamation / hyperkeratosis / acanthosis |
Outline of Final Research Achievements |
Total loss of Cathepsin C ( CTSC ) activity cause Papillon-Lefevre syndrome ( PLS ), which characterized by palmoplantar keratoderma ( PPK ). CTSC knock out mice naturaly lack PPK, so we examined whether inflammation trigger a change of epidermal differentitation in CTSC knock out mice. We made four groups, knock out mice and wild type mice with or without application of TPA. We confirmed that knock out mice with application of TPA had feeature of palmplanterkeratosis,remarkable hyperkeratosis and acanthosis histologically. This research sugesut that skin manifestation of Pappilion Lefevre syndrome caused by irritation,so skin change localize palmplanter,knee,elbow in PLS.
|
Free Research Field |
医師薬学
|