Function of lymphatics in tumor immunity, vasculitis, and imiquimod-induced psoriasis-like dermatitis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591623
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: The University of Tokyo
• Principal Investigator: SUGAYA Makoto 東京大学, 医学部附属病院, 准教授 (90334408)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: リンパ / 腫瘍免疫 / リンパ節 / CD8陽性細胞 / アルサス反応 / Fcγ受容体

Outline of Final Research Achievements

Primary tumor growth was augmented in lymphedematous mice when B16 melanoma cells were subcutaneously injected. Expression of inflammatory cytokines as well as tumor-associated antigens in draining lymph nodes was significantly reduced in lymphedematous mice compared to wild-type mice. CD8+ T cells in draining LNs derived from lymphedematous mice bearing B16 melanoma also showed significantly decreased cytotoxic activity in vitro and in vivo. In summary, these findings suggest that lymphatic transport is essential in generating optimal tumor-specific immune responses. Moreover, early phase of leukocytoclastic vasculitis, the cutaneous and peritoneal reverse Arthus reactions, was attenuated in lymphedematous mice. Decreased Fc gamma receptor III expression on mast cells and macrophages may have resulted in reduced inflammation.

Free Research Field

皮膚科学