2014 Fiscal Year Final Research Report
A role of CD22 and CD72 in the immune responses
| Project/Area Number |
24591645
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | B細胞 / CD22 / CD72 |
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| Outline of Final Research Achievements |
In this study, we addressed whether CD22 and CD72 have redundant functions using CD22 and CD72 double-deficient (CD22-/-/CD72-/-) mice. CD22-/-/CD72-/- mice showed significantly decreased number of peripheral B cells compared to wild type mice. Turnover of B cells in CD22-/-/CD72-/- mice was significantly augmented than in wild type mice, but significantly reduced compared to CD22-/- mice. CD22-/- mice showed significantly increased serum IgM levels compared to wild type mice, but CD22-/-/CD72-/- mice did not. IgM responses against DNP-Ficoll were significantly decreased in CD22-/-/CD72-/- mice compared to wild type mice. In pristane-induced murine lupus model, both the incidence of ANAs and urine protein levels were similar between wild type and CD22-/-/CD72-/- mice. These results showed that abnormalities observed in CD22-/-/CD72-/- mice did not exceed the degree of those seen in each-deficient mice. Therefore, we concluded that CD22 and CD72 independently regulated B cell function.
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| Free Research Field |
皮膚科学
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