Regulation of skin immunity by regulatory T cell-subset

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591649
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kyoto University
• Principal Investigator: NOMURA Takashi 京都大学, 医学(系)研究科(研究院), その他 (60346054)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 皮膚免疫学 / 免疫制御 / アレルギー / 免疫寛容

Outline of Final Research Achievements

Although etiology of atopic dermatitis, psoriasis, and collagen diseases is not fully clarified, it is partly explained by excessively activated immune system. Such over-activation is inhibited by special lymphocytes called regulatory T cells. In this project, we developed Helios-reporter mice, in which Helios-expressing cells expressed fluorescent proteins; and we analyzed live regulatory T cells expressing Helios. Our study revealed that Helios-expressing regulatory T cells possessed a strong suppressive activity. Helios-reporter mice are applicable for developing measures to restrain excessive immune responses or to treat allergic and autoimmune diseases.

Free Research Field

皮膚科学・免疫学