Contribution of mast cell functions to the pathogenesis of allergic inflammatory diseases and role of Notch signaling in regulating mast cell functions

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591667
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Juntendo University
• Principal Investigator: NAKANO Nobuhiro 順天堂大学, 医学(系)研究科(研究院), 助教 (30420839)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アレルギー / マスト細胞 / Notchシグナル / サイトカイン

Outline of Final Research Achievements

Cytokines produced by mast cells play an important role in the pathogenesis and exacerbation of allergic inflammatory diseases. This study revealed that signaling through cell surface Notch receptors enhances the production of Th2 and inflammatory cytokines by mast cells through direct and indirect mechanisms. Furthermore, results from this study suggest that Notch signaling contributes to the maturation of mucosal-type mast cells, and thus I have analyzed the molecular mechanisms of Notch-induced mast cell maturation.

Free Research Field

アレルギー学