Analysis of mice that carry disruption in Disc1, a schizophrenia risk gene

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591681
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Osaka University (2013-2014); Okayama University (2012)
• Principal Investigator: MIYOSHI Ko 大阪大学, 連合小児発達学研究科, 助教 (90362996)
• Co-Investigator(Kenkyū-buntansha): WAKANA Shigeharu 独立行政法人理化学研究所, バイオリソースセンター, チームリーダー (90192434)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: Disc1

Outline of Final Research Achievements

Disc1 is a risk gene of schizophrenia, a common psychiatric disease. In this research, difference between Disc1-lacking mice and wild-type mice was analyzed. No significant difference was found in regard to the cell architecture and neurite extension of neurons in various brain regions, and to neurogenesis in the developing cerebral cortex and in the hippocampal dentate gyrus of adult mice. In the behavior tests implicated as a hallmark for psychiatric disorders, Disc1-lacking mice demonstrated higher locomotor activity and a lower score in the contextual fear conditioning compared to wild-type mice.

Free Research Field

神経科学