The association between chorein and mitochondria-related cell death

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591685
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kagoshima University
• Principal Investigator: NAKAMURA Masayuki 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (90332832)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 有棘赤血球舞踏病 / chorein / オートファジー / マイトファジー

Outline of Final Research Achievements

Co-immunoprecipitation assay and immunocytochemical analysis using chorein-overexpressing cells showed interaction between chorein and cytoskeltal proteins and autophagy-related proteins. The chorein-cytosleltal proteins iteraction was increased in CCCP-treated cells. Cell viability was significantly increased in chorein-overexpressing cells compared with mock transfected control cells during nutrient deprivation and during CCCP treatment. These results suggest that chorein interacts with cytoskeltal proteins and autophagy-related proteins and may play protective roles in cell death mediated by autophagy- and mitophagy-related mechanisms. Their disruption may be one of the molecular pathogenic mechanisms of chorea-acanthocytosis.

Free Research Field

精神神経医学