2014 Fiscal Year Final Research Report
Role of complement regulatory factors in synapse pruning and in schizophrenia pathogeny
| Project/Area Number |
24591687
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUBOI Akio 奈良県立医科大学, 医学部, 教授 (20163868)
FUKAMI Shin-ichi 奈良県立医科大学, 医学部, 助教 (90424150)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 統合失調症 / シナプス / 補体 / iPS細胞 |
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| Outline of Final Research Achievements |
The pathology or pathophysiology of schizophrenia is still unclear. Recent genetic studies revealed complement regulatory factors as schizophrenia candidate genes. Additionally, studies of cell biology and neuroimmunology have reported activation of complement cascade plays an important role in synapse pruning in developing mouse brain. According to these findings, we suppose the deficit of synapse pruning due to complement dysregulation as a new pathological model of schizophrenia. In our study of cell culture model, neurons differentiated from iPSCs of schizophrenia patient and his discordant twin sibling showed lower expression of complement regulatory factor CSMD1 than that of control subject, and synapse formation was impaired in neurons of schizophrenia patient.
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| Free Research Field |
精神医学
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