Clinical study of preclinical useful diagnosis of Alzheimer's Disease using by MRI and periperal biomarkers

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591695
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Tohoku University
• Principal Investigator: WARAGAI Masaaki 東北大学, 加齢医学研究所, 非常勤講師 (50533775)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アルツハイマー病 / バイオマーカー / 神経変性疾患 / MRI

Outline of Final Research Achievements

We studied methods of early diagnosis for Alzheimer's Disease(AD)/Mild Cognitive Impairment(MCI).We showed that MRI using by VSRAD　combined with MRS(magnetic resonance spectroscopy) of the brain is useful for early diagnosis and tracking progression of AD.　We found acrolein, a product of lipid peroxidation related factors are changed in the biofluids in MCI/AD. Furthermore, we also showed plasma p3-Alcα35, a mojor fragment of Alcadeinα by γ-secretase clevage are increased in AD suggesting plasma p3-Alcα35 could be good biomarker for MCI/AD.
Thus, we found potentially useful peripheral biomarkers and demonstrated MRI/MRS are useful for screening of AD in clinical practice.

Free Research Field

老年期神経変性疾患