Comprehensive research on the pain-relieving effects of duloxetine in BMS patients

2017 Fiscal Year Final Research Report

• Project/Area Number: 24591703
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Nagoya University
• Principal Investigator: KIMURA HIROYUKI 名古屋大学, 医学系研究科, 講師 (50378030)
• Co-Investigator(Kenkyū-buntansha): 栗田 賢一 愛知学院大学, 歯学部, 教授 (40133483) ; 伊藤 幹子 愛知学院大学, 歯学部, 非常勤講師 (50469003)
• Co-Investigator(Renkei-kenkyūsha): OZAKI Norio 名古屋大学, 医学系研究科, 教授 (40281480)
• Research Collaborator: YOSHIDA Keizo 株式会社デンソー, 健康推進部, 課長格主任部員 ; TOKURA Tatsuya 名古屋大学, 医学系研究科, 助教 ; NAGASHIMA Wataru 名古屋大学, 医学系研究科, 助教
• Project Period (FY): 2012-04-01 – 2018-03-31
• Keywords: 疼痛性障害 / 口腔内灼熱症候群 / リエゾン精神医学 / 抗うつ剤

Outline of Final Research Achievements

We examine the relationship between the pain-relieving effects of duloxetine, its plasma concentrations and neuroinflammation-related substances (cytokine, chemokine, BDNF, NGF) in patients with chronic nonorganic pain in the orofacial region. Duloxetine significantly relieved pain in patients with chronic nonorganic pain. However, no relationship was observed between its pain-relieving effects and plasma concentrations. Neuroinflammation-related substances is currently under consideration. Additionally we investigated the personality traits of Burning mouth syndrome (BMS) patients. The novelty seeking score was low in BMS patients. They also had high harm avoidance and low self-directedness tendencies.
This research was conducted in collaboration with Department of Psychiatry Nagoya University Graduate School of Medicine and Department of Oral and Maxillofacial Surgery School of Dentistry Aichi Gakuin University.

Free Research Field

精神神経学