Neuroanatomic pathways associated with poststroke affective and apathetic depression.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591715
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Hiroshima University
• Principal Investigator: YAMASHITA Hidehisa 広島大学, 大学病院, 講師 (50294591)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脳卒中後うつ病 / MRI / SPM / 抑うつ気分 / アパシー / 脳幹 / 基底核 / 左側前頭葉

Outline of Final Research Achievements

METHODS: Magnetic resonance imaging acquisitions were obtained from 149 poststroke patients, who were assessed for affective and apathetic symptoms using the Hospital Anxiety and Depression Scale and the Apathy Scale, respectively. We created a statistical parametric map that displayed an association between lesion location and affective and apathetic symptoms.
RESULTS: Among the patients with higher depressive scores, the lesion overlap centered on the brainstem, left basal ganglia, and left frontal cortex. Among the patients with higher apathy scores, the lesion overlap centered on the brainstem and bilateral striatum. The overlap lesion for both affective and apathetic depression centered mainly on the brainstem; however, the two types of depression often did not overlap. CONCLUSIONS: Two core symptoms that can occur after stroke, affective and apathetic symptoms, appear to be associated with different monoaminergic neuroanatomic pathways (serotonergic and dopaminergic).

Free Research Field

精神医学