A study to investigate biomarkers of metabolic syndrome in pervasive developmental disorder

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591724
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Sapporo Medical University
• Principal Investigator: TATENO Masaru 札幌医科大学, 医学部, 研究員 (60464492)
• Co-Investigator(Kenkyū-buntansha): UKAI Wataru 札幌医科大学, 医学部, 講師 (40381256) ; FURUHASHI Masato 札幌医科大学, 医学部, 助教 (20563852) ; WATANABE Kimihiko 札幌医科大学, 医学部, 研究員 (70464493)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 広汎性発達障害 / 自閉症 / メタボリック症候群 / 肥満

Outline of Final Research Achievements

The purpose of this study is to investigate the biological mechanisms of metabolic syndrome (MS) in pervasive developmental disorder (PDD). Since the risk of MS could be increased as the people become older generally, the subjects of this study were limited to young youth cases. We developed database of clinical features of the subjects and analyzed the data comprehensively. As a biological investigation, we measured adipocytokines, such as Adiponectin, Leptin, TNF-alpha, IGF-1, Resistin, TGF-beta, IL-6, and PAI-1, in serum of PDD subjects by using Enzyme-Linked Immuno Sorbent Assay (ELISA). We also examined the effect of fatty acid-binding protein (FABP) on the neurogenesis from neural stem cells (NSC) obtained from rat embryos. The results demonstrated that FABP4, which has been reported to be related to MS, might increase the number of neurons from NSC at certain concentration.

Free Research Field

医歯薬学