Creation of novel model mice for dementia research and development of new medicines for dementia treatment.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591738
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: HOSOKAWA Masato 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 主席研究員 (00435116)
• Co-Investigator(Renkei-kenkyūsha): AKIYAMA Haruhiko 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 参事研究員 (20231839)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 認知症 / TDP-43 / tau / 疾患モデルマウス / タンパク質異常凝集 / グラニュリン

Outline of Final Research Achievements

Nobel mice model regarding dementa research were produced for discovering effective drugs. These mice over expressed neurodegenerative diseases associated protein by doxycycline. The abnormal aggregations of these proteins have not observed in neuronal cells yet because aging of mice is not sufficient or other reasons. The results of the other model mice suggest that granulin mutations might contribute to the pathogenesis or be risk factors for tauopathies, including Alzheimer’s disease or corticobasal degeneration.

Free Research Field

神経変性疾患