Comprehensive risk assessment by using myocardial flow reserve in patients with diastolic dysfunction

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591742
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: Naya Masanao 北海道大学, 大学病院, 講師 (20455637)
• Co-Investigator(Kenkyū-buntansha): KINUGAWA SHINTARO 北海道大学, 大学院医学研究科, 講師 (60399871) ; IWANO HIROYUKI 北海道大学, 北海道大学医院, 医員 (50622354) ; MANABE NORIKO 北海道大学, 北海道大学病院, 講師 (70463742)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 心不全 / 心臓交感神経 / 心臓PET

Outline of Final Research Achievements

The present study focused on the assessment of diastolic dysfunction in terms of cardiac PET in patients with heart failure. Understanding the mechanism of diastolic dysfunction can help develop new effective treatment and tailor-made therapy. Forty-one patients with heart failure and preserved ejection fraction were studied. Cardiac sympathetic function was evaluated by C11-HED PET. Cardiac sympathetic function in patients with moderate to severe diastolic dysfunction was significantly decreased than that in normal to mild function.

Free Research Field

循環器内科