Establishment of myocardial fibrosis quantification method using delayed contrast-enhanced MRI

2015 Fiscal Year Final Research Report

• Project/Area Number: 24591776
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagasaki University
• Principal Investigator: SUEYOSHI Eijun 長崎大学, 病院(医学系), 講師 (40380894)
• Co-Investigator(Renkei-kenkyūsha): SAKAMOTO Ichiro 長崎大学, 医歯薬総合研究科(医学系), 准教授 (00225806)
• Research Collaborator: HAYASHIDA Takeshi ; KOTAKE Takako
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: MRI / 心筋遅延造影法 / 心筋線維化 / 定量化法

Outline of Final Research Achievements

To estimate diffuse myocardial fibrosis with cardiac MRI in patients with dilated cardiomyopathy (DCM) using myo- cardial T1 value.
Delayed enhancement imaging was performed in 52 patients with DCM and 10 control subjects to identify fibrosis using an inversion time scout sequence. The mean contrast-enhanced myocardial (M) T1 values of the pre and post contrast-enhanced myocardial and left ventricular lumen (L) of control and dilated cardiomyopathy cases were compared. The calculated post M T1 value, pre M T1 value-post M T1 value, and (pre M TI value-post M T1 value)/(pre L T1 value-post L T1 value) were significantly different between the patient group and the control group. (Pre M T1 value-post M T1 value)/(pre L T1 value-post L T1 value) was significantly the most re-lated to the left ventricular ejection fraction (r = 0.66, p < 0.0001). (Pre M T1 value-post M T1 value)/(pre L T1 value-post L T1 value) was the most reliable quantification method to estimate the severity of DCM.

Free Research Field

放射線医学