Development of functional brain imaging analysis system of Alzheimer's disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591786
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: MATSUDA HIROSHI 独立行政法人国立精神・神経医療研究センター, 脳病態統合イメージングセンター, センター長 (90173848)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: PET / アルツハイマー病 / アミロイド

Outline of Final Research Achievements

Analysis of amyloid amount deposited to the cerebral cortex, which can be estimated from an amyloid PET image, is effective for early diagnosis of Alzheimer’s disease (AD). Nevertheless, its quantifiable measure is hampered by the partial volume effect (PVE) due to the low spatial resolution, because the amount of amyloid deposition is thereby underestimated. In this work, we proposed a method using SPM8 to correct PVE and to improve its quantifiable measure of amyloid deposition amount based on morphological information of CT image, which is simultaneously acquired by a PET/CT scanner. The procedure was applied to clinical data of nine AD patients and eleven normal volunteers, and then emphasized the difference between the normal and AD groups in standardized uptake value ratio values in the eight areas effective for AD diagnosis. In addition, we demonstrated the effectiveness by comparing area under ROC curve between the results with and without the partial volume correction.

Free Research Field

脳核医学