The prognostic analyses by PET/CT and signal transduction pathway in 150 lung cancer patients.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24591797
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kurume University
• Principal Investigator: KAIDA Hayato 久留米大学, 医学部, 助教 (40299425)
• Co-Investigator(Kenkyū-buntansha): FUJIMOTO Kiminori 久留米大学, 医学部, 准教授 (00199366) ; AZUMA Koichi 久留米大学, 医学部, 講師 (00368896) ; HAYABUCHI Naofumi 久留米大学, 医学部, 教授 (20108731) ; ISHIBASHI Masatoshi 久留米大学, 医学部, 教授 (20168256) ; TAKAMORI Shinzo 久留米大学, 医学部, 教授 (50197028) ; HATTORI Satoshi 久留米大学, バイオ統計センター, 教授 (50425154) ; KAGE Masayoshi 久留米大学, 大学病院, 教授 (80148840) ; KURATA Seiji 久留米大学, 大学病院, 講師 (80268888)
• Co-Investigator(Renkei-kenkyūsha): HATTORI Satoshi 久留米大学, バイオ統計センター, 教授 (50425154)
• Research Collaborator: HAYABUCHI Naofumi ; ISHIBASHI Masatoshi
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 核医学 / ＦＤＧ－ＰＥＴ / 肺癌 / 癌増殖シグナル伝達因子

Outline of Final Research Achievements

The aim of this study was to investigate the correlation between 18F-fluorodeoxyglucose (18F-FDG) uptake and cancerous signal transduction pathway, and assess the appropriate 18F-FDG uptake parameters [maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis(TLG)] and cancerous signal transduction factors for survival rate in 150 completely surgically resected non-small cell cancer (NSCLC) patients. We found that signal transducer and activator of transcription-1 (Stat-1) and Stat-3 were related with Glucose transporter-1 (Glut-1) which is 18F-FDG uptake determined factor. The signal transduction factors correlated with 18F-FDG uptake parameters were Glut-1 and Stat-3. With regard to prognosis of NSCLC patients, all 18F-FDG uptake parameters are associated with survival rate of NSCLC.

Free Research Field

放射線医学（核医学）