2014 Fiscal Year Final Research Report
The research for the mechanisms and protection method of radiation-induced suppression of myotube formation
| Project/Area Number |
24591839
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Gihu University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 筋芽細胞 / 筋管形成 / 筋管形成阻害 / 増殖因子 / IGF-1 / FGF-2 / HGF / C2C12 |
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| Outline of Final Research Achievements |
I investigated the mechanisms and the protection methods of X-ray-induced delay of myotube formation. I evaluated the alterations of gene expressions of four key transcription factors and demonstrated the decrease in myogenin gene expression related to the X-ray-induced decrease in myotube formation. I also find that the cell cycle distributions and cell growth state of C2C12 cells affected the effects of X-ray irradiation on myotube formation. In addition, I showed that fibroblast growth factor and/or hepatocyte growth factor had the ability to protect the X-ray-induced decrease in myotube formation if these growth factors appropriately used in the point of concentration and/or time point, and so on.
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| Free Research Field |
放射線生物学
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